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This paper explores the pivotal role of Machine Learning in transforming Cyber-Physical Systems, a field where the integration of physical processes with computational models offers substantial advancements in various sectors. ML has proven instrumental in enhancing predictive capabilities, optimizing system operations, and strengthening data security within CPS. As industries such as healthcare, smart infrastructure, and transportation continue to adopt CPS technologies, ML has become a critical enabler for real-time data analysis, anomaly detection, and automated decision-making, fostering more efficient and intelligent systems. The growing reliance on CPS for mission-critical applications necessitates robust solutions for managing vast amounts of data and ensuring system reliability. However, despite these advancements, significant challenges persist, including concerns around privacy, adversarial attacks, and scalability. These issues present barriers to the widespread deployment and trust in CPS technologies. This paper provides a comprehensive examination of ML's transformative impact on CPS, emphasizing its role in overcoming operational challenges and enhancing system resilience. Additionally, it discusses the importance of developing more secure, scalable, and transparent ML models that can address the evolving needs of CPS. Future research will focus on refining these techniques, improving model interpretability, and implementing more adaptive solutions to meet the demands of an increasingly interconnected world.